Depression
Research studies state , “ ketamine was found to exert a rapid and sustained antidepressant effect on samples of treatment resistant patients”.
Serafini G, Howland RH, Rovedi F, Girardi P, Amore M. The role of ketamine in treatment-resistant depression: a systematic review. Curr Neuropharmacol. 2014 Sep;12(5):444-61.
doi: 10.2174/1570159X12666140619204251. PMID: 25426012; PMCID: PMC4243034.
Yale medicine explains ketamine and depression in this youtube video:
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Anxiety
Taylor JH, Landeros-Weisenberger A, Coughlin C, Mulqueen J, Johnson JA, Gabriel D, Reed MO, Jakubovski E, Bloch MH. Ketamine for Social Anxiety Disorder: A Randomized, Placebo-Controlled Crossover Trial. Neuropsychopharmacology. 2018 Jan;43(2):325-333. doi: 10.1038/npp.2017.194. Epub 2017 Aug 29. PMID: 28849779; PMCID: PMC5729569.
PTSD
Studies show “ repeated ketamine administration in individuals with chronic and severe PTSD revealed large-magnitude improvements in PTSD symptoms”.
A Randomized Controlled Trial of Repeated Ketamine Administration for Chronic Posttraumatic Stress Disorder.Adriana Feder, Sara Costi, Sarah B. Rutter, Abigail B. Collins, Usha Govindarajulu, Manish K. Jha, Sarah R. Horn, Marin Kautz, Morgan Corniquel, Katherine A. Collins, Laura Bevilacqua, Andrew M. Glasgow, Jess Brallier, Robert H. Pietrzak, James W. Murrough, and Dennis S. Charney
American Journal of Psychiatry 2021 178:2, 193-202
Citations:
1.Ketamine for the acute treatment of severe suicidal ideation: double blind, randomised placebo controlled trialBMJ 2022; 376
doi: https://doi.org/10.1136/bmj-2021-067194 (Published 02 February 2022) BMJ 2022;376:e067194
2.Efficacy of ketamine therapy in the treatment of depression Indian J Psychiatry. 2019 Sep-Oct; 61(5): 480–485.
doi: 10.4103/psychiatry.IndianJPsychiatry_484_18
3. American Psychiatric Association 2022. Psychiatry.org
4. Serafini G, Howland RH, Rovedi F, Girardi P, Amore M. The role of ketamine in treatment-resistant
depression: a systematic review. Curr Neuropharmacol. 2014 Sep;12(5):444-61. doi:
10.2174/1570159X12666140619204251. PMID: 25426012; PMCID: PMC4243034.
5.Management of treatment-resistant generalized anxiety disorder - PMC.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7653736/
Sep;12(5):444-61. doi: 10.2174/1570159X12666140619204251. PMID: 25426012; PMCID: PMC4243034.